Spherical Crystallization as a New Platform for Particle Design Engineering
This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-,pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.
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Kawashima, Yoshiaki
[Current Position and Affiliations]Contract Professor of Pharmaceutical Technology, Faculty of Science, Aichi Gakuin University, Kusumoto, Chikusaku, Nagoya 464- 8650, JapanEmeritus Professor of Gifu Pharmaceutical University, Daigaku Nishi, Gifu 501- 1113, Japan[Fields and Areas of Specialization]Particulate design engineering for drug delivery systems including spherical crystallization,agglomeration, microencapsulation, nanocapsule[Education]1964, March B. Pharm. Nagoya City University, Japan1966, March M. Pharm. Kyoto University, Japan1970, January Ph. D. Kyoto University, Japan[Position Held]1969, April Assistant Professor, Gifu Pharmaceutical University1972-74 Postdoctoral Fellow, National Research Council of Canada1977 Invited Visiting Scientist, National Research Council of Canada1978, April Associate Professor, Gifu Pharmaceutical University1983, April Professor, Gifu Pharmaceutical University1986 Invited Visiting Professor (JSPS), National University of Singapore1991 Invited Visiting Professor, Shenyang Pharmaceutical University[Award](1) The Most Promotive Research Work Award, 1986 from Pharmaceutical Society of Japan (2) The 4th Upjohn Fellowship for Scientific Research 1990 for "Particle Design for Development of Novel Dosage Forms"(3) The Science Award, 1992 from The Academy of Pharmaceutical Science and Technology, Japan(4) The Conference Pharmaceutiques Barre 1993 from The Faculty of Pharmacy, University of Montreal (Canada)(5) The 9th Annual Colorcon Award, 1995 from FIP (International Pharmaceutical Federation) Foundation for Education and Research(6) American Association Pharmaceutical Scientist (AAPS) Fellow (Seattle, 1996)(7) The Best Paper Award, 1997 from the Academy of Pharmaceutical Science Technology, Japan(8) KONA Award, 1998 from the Hosokawa Powder Technology Foundation(9) Science Award, 2000 from Gifu News Paper Press(10) Pharmaceutical Sciences World Congress (PSWC) Research Achievement Award, 2004 (11) Swiss Galenic Pharmaceutical World Fellow, 2004(12) International Fellow of the Academy of Pharmaceutical Science Technology, Japan, 2010[Society Membership]The Academy of Pharmaceutical Science and Technology, Japan (Council Member) The Society of Powder Technology, Japan (President past, Chairman of The Division of Pharmaceutical Preparations and Particulate Design past) The Association of Powder Process Industry and Engineering, Japan (Vice President past)Pharmaceutical Society of Japan (Council Member, past)Japan Society of Drug Delivery System (Council Member)International Pharmaceutical Federation, FIP (Board of Pharmaceutical Sciences)Japan Society of Pharmaceutical Machinery and Engineering President past, Council¿ Member)American Association of Pharmaceutical Scientists (Fellow) Controlled Release Society, and others[Editor and Editorial Advisory Board]S. T.P. Pharma Sciences J. Drug Delivery Sci. Technol.(Editor in Chief for Japan past)Asian J. Pharm. Sci. Technol. (Editor in Chief for Japan past)European Journal of Pharmaceutics and Biopharmaceutics (Pacific Rim Editor past)Journal of Microencapsulation (Regional Editor past)Powder TechnologyJournal of Controlled ReleaseAdvanced Powder TechnologyThe Chinese Pharmaceutical JournalChemical Pharmaceutical Bulletin (past)Journal of The Society of Powder Technology, Japan (past)Yakugaku Zasshi (past)[Publication]Original Research Papers, 306 Patents, 35
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