Neurologie

La crise sanitaire que nous traversons à l'heure où ces lignes sont écrites, nous permettra-t-elle, après-coup et collectivement, de considérer et de construire un monde qui puisse accueillir une humanité qui ne soit pas/plus uniquement celle des ' nouvelles humanités ' des sociétés post-modernes et de l'ère Anthropocène où l'humain est devenu un transhumain, voire un post-humain ? Quels risques pour la condition humaine comportent ces mutations ? La dialectique pensée/agir au coeur de cette réflexion nous permettra, très certainement, d'entrevoir, par l'attention accordée aux modalités et aux enjeux de ces ' nouvelles humanités ', les risques sous-tendus eu égard à la condition humaine ainsi que les potentialités de devenir qu'ils comportent.

This book explains the fundamental characteristics and biofunctionality of Alzheimer's Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer's Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer's disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer's disease treatment.

The African narrative on autism is about to change. "Beyond the Mask: Autism in Africa" sheds light on the experiences of individuals with Autism Spectrum Disorder (ASD) across the continent. This groundbreaking book challenges the misconception of ASD being a Western phenomenon."Beyond the Mask" explores the unique cultural understanding and presentation of ASD in Africa. Delve into the challenges faced by families and individuals, often due to limited diagnosis, resources, and societal awareness. Yet, the book also celebrates the resilience and strength of African communities in supporting their autistic loved ones.This book is more than just raising awareness. It empowers families, educators, and healthcare professionals with practical guidance and resources. "Beyond the Mask" calls for a more inclusive Africa that embraces neurodiversity and unlocks the full potential of autistic individuals. Join us on this journey to see autism in Africa, beyond the mask.

Covering all aspects of CNS tumors pathology, this book provides complete information on tumors of the brain and its coverings, sellar region, pineal region, and cranial and paraspinal nerves according to 2021 WHO classification, 5th edition, including new entities, as well as benign cysts and nonneoplastic disorders that are potentially misinterpreted as neoplasms. Throughout the book, emphasis has been placed on histopathologic characteristics and differential diagnosis, which are summarized in tables to make the explanation of certain topics clearer.This valuable text also includes the most recent clinical, pathological, histological, cytological, and molecular knowledge in the field, enabling pathologists to arrive at the correct diagnosis and prepare actionable, useful reports. Since pathology is one of the most visually oriented medical specialties, the myriad of annotated images throughout has been evaluated carefully and include neuroimaging studies, histology, cytology, and immunohistochemical stains that support a morphologic discussion in which differential diagnosis and potential pitfalls are emphasized. Central Nervous System Tumors: Diagnostic Pathology provides a comprehensive guide of the current critical information needed to recognize, understand, and interpret this demanding field of surgical neuropathology. It is designed with the needs of practicing surgical pathologists, pathologists-in training, and clinicians in mind.

This book includes 35 vertigo cases, which covers typical cases, difficult cases and rare cases from the department of otorhinolaryngology, neurology, emergency department, geriatrics, ophthalmology, and other disciplines. In each case, it has uniform structure, which includes summary of medical records, case study and case view.This book starts from peripheral vertigo, which is the most common vertigo disease, and belong to vestibular vertigo. It also covers non-vestibular vertigo, which is rare and might be ignored to get timely diagnosis and treatment. In addition, it introduces the patient who have multiple vertigo diseases, which are difficult to diagnosis and treatment, but also easy to be missed or misdiagnosed.This book will be helpful to deeply understand vertigo diseases and improve the diagnosis and treatment of vertigo diseases.The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content.

This book provides an overview of planning and examining the methodology, analytic issues, primary and secondary endpoints and outcomes in headache trials. Throughout the book, guidance on how to design a high quality study and how to evaluate which study has relevant scientific qualification is discussed in detail. Clinical scales and patient related outcome measures (PROMs) to exclude secondary headaches, to diagnose primary headache disorders, to evaluate patients' health-related quality of life, to detect psychiatric comorbidities, to assess patients' headache-related disability and to monitor patients' treatment optimization are clearly and concisely outlined in the chapters. Clinical Scales for Headache Disorders highlights the components for planning an effective headache study including interpretation of primary and secondary endpoints, common clinical scales, PROMs and their clinical reliability and validation. Both clinicians and researchers willfind this book to be a useful tool for their medical and academic practices on headache and migraine.

Degenerative, Deformity, Trauma, Oncological, Inflammatory/rheumatological, Spinal cord injury.- Bone metabolism: Assessing (DEXA, CT Scan) and medical management advances.- Anticoagulation and spine disease in the elderly.- Managing multiple medical comorbidities - DM, Cardiopulmonary, Obesity/Fraility.- Anesthetic Concerns and adaptions in the elderly.- PreHab/Rehab.- ERAS.- Surgical treatment of myelopathy.- Atlantoaxial fractures in the elderly.- MIS Cervical Approaches in the elderly.- Subaxial spine trauma.- Anterior vs Posterior Approaches in the Elderly.- Management of Ankylosing Spondylitis, DISH, and OPLL.- Cervical spine deformity in the elderly .- Spinal cord injury.- Cervical oncology.- Spondylolisthesis treatment in the elderly.- Lumbar stenosis.- Sagittal plane deformity considerations in the elderly.- Revision surgery in the elderly.- Thoracolumbar Trauma.- Osteomyelitis.- Thoracolumbar oncology.- Interbody arthrodesis advancements.- Pedicle screw fixation advancements.- EOS and full body imaging.- Navigation & robotics.- Awake spinal surgery.- Endoscopy.- CT-Guided radiofrequency ablations.- SCS.- DRGS.- Sacro-iliac interventions.

Maggie Morris resembles a human. Unknown and unattached, she moves seamlessly through her days, a polished collection of patterns. Her only honest relationship is with the dormant tree outside her Brooklyn loft window. When she unexpectedly runs into her childhood best friend, Dana, a Tsalagi girl who disappeared the summer they turned nine, Dana's cryptic references about the events surrounding her disappearance launch Maggie down a rabbit hole of questions, not only about that long-ago summer but about who she's become and why. Magpie explores appropriation and masking as the means through which an undiagnosed autistic woman builds a functional identity, burying her true one in the process. Maggie is difficult, odd, and soulful-in search of not only answers to a childhood mystery but an authenticity she has no idea how to recognize.

Come On In comes from a place of love and respect and, in retrospect, a way of coping when a loved one is diagnosed with Vascular Dementia. Vascular Dementia showed its true colours to our family as the cruel disease that it is; a disease which dismantles the personality and destroys the lives of those who love them as they endure the agony of watching the afflicted person slowly fade away. My daughter, Michelle, and I have written this book to offer comfort to the relatives of other victims of this devastating disease. We want you to know you are not alone, and we hope that our experiences will support you on your journey and that the tips we share with you will help you as you find your own way to cope.

Historically, there has been an expectation that autistic children and adults should conform their behaviour to social norms, with strategies and interventions centred around navigating spaces and situations with minimal damage. This person-centred environmental assessment and modification programme moves away from this, with the aim to provide information and tools for assessing and reflecting on features of the autistic person's environment to best support their comfort, autonomy and agency. Written as a collaboration between autistic and non-autistic professionals, the authors break down each environmental element (physical, sensory, emotional, communicative and social) by chapter and include checklists as reference points to equip the reader with a framework from which to begin. This accessible, strengths-focused approach to supporting autistic people across different areas of their life reflects a paradigm shift from one where autism is treated as a deficit or impairment to one of strength, acceptance and autonomy.

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This book offers a detailed description of the main barbed pharyngoplasty techniques for the treatment of obstructive sleep apnea. These innovative techniques have spread in recent years and are considered as a validated alternative to the classic respective techniques.The book covers the barbed pharyngoplasty selection criteria, the surgical technique, and discusses the post-operative results. It also includes some chapters on the experience of surgical sleep centers in various parts of the world.Written by leading experts in the field of sleep surgery, this book will be interesting for ENT specialists, oral surgeons, maxillo-facial surgeons, plastic surgeons, sleep doctors, neurologists and pneumologists.

Alzheimer's disease is the most prevalent form of dementia. Although it was discovered about a century ago, the first drugs applied in treatment were only introduced in therapy in the last 30 years.This book focuses on the clinical pharmacology of drugs that aim to delay the progression of Alzheimer's disease, such as anticholinesterases and glutamate receptor antagonists, as well as treatment for the behavioral changes caused by the progression of the disease: antidepressants, antipsychotics, anxiolytics, and mood stabilizers.In addition, it describes important information about the pathophysiology and diagnostic methods of Alzheimer's disease, emergency situations conditioned by the dementia process, and presents new perspectives for the treatment of Alzheimer's disease. The ten chapters cover topics such as mechanism of action, dosage regimen, adverse reactions, drug interactions, toxicity profiles, among other information of clinical relevance. The work comprises evidence-based studies, providing a valuable resource for analyzing, prescribing and monitoring patients being treated for Alzheimer's disease.Written by experts with solid professional experience, this book will appeal to pharmacologists, geriatricians, neurologists, psychiatrists, biomedical clinicians, and other healthcare professionals.

This book explores connections between music, neural activations and brain plasticity, in order to better understand its associated psychological and physiological effects. The final goal is to focus on the positive effects of music to treat neurological disorders, establishing a new co-ordination between different brain areas to improve both mental illness and wellbeing. A secondary goal is to analyse the role of music at a psycho-sociological level, to understand both the transformation of music into a cultural model and the vision of music as an innate instinct.Music is able to create both emotions and volitional processes. The application of new neuroimaging techniques allows us to explore and evaluate with accuracy what happens in our brain during the creative and artistic performance. A wide range of brain regions are recruited for creative tasks, and music has the opportunity to help in enhance and reset some brain pathological disturbances being also able to ameliorate and restore some rhythmic body activities such as sleep, movement and co-ordination.The book represents a valuable and innovative tool both for neurologists as well as healthcare professionals involved in the management of neurological disorders.

This book talks about the levels of consciousness and their roles in controlling our life and behaviour. The consciousness has a main role in learning human to behave and to live in all life's situation and ages. This book clarifies these situations in details and the laws that make this system work properly. It provides many solutions and suggestions to control ourselves and our minds and put them in the right way. This book explains many of our behaviours depending on the psychology and the role of the consciousness in the psychiatry, how to treat diseases and mental disorders and how to improve the mental health as well.This subject is not well discussed and detailed in literature so there is a need to give this topic its role in the psychology and in scientific literature too.This book is targeting the consciousness' levels and the role of these levels in our life and behaviours, so it divides the roles among them as appropriate and in the right way and then the humans can recognize which part is more important than the other and on what they should focus.