Allgemeines & Erfahrungsberichte

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.¿

The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

When the woman he loved was diagnosed with a metastatic cancer science-writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now under way - an explosion of new ideas about what cancer really is and where it comes from. He combs through the realms of epidemiology clinical trials laboratory experiments and scientific hypotheses to reveal what we know and don't know about cancer showing why a cure remains such a slippery concept. His luminous accounts describe tumors that evolve like alien creatures inside the body paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors and the surprising reversals in science's comprehension of the causes of cancer with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them against the body.Throughout his pursuit Johnson illuminates the human experience with elegiac grace bearing witness to the punishing gauntlet of consultations surgeries targeted therapies and other treatments. Provocative and intellectually vibrant The Cancer Chronicles will challenge everything you thought you knew about the disease - and provide hope for tomorrow and the future.

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In jüngster Zeit hört man immer wieder von Krebsopfern, die von dieser schrecklichen Krankheit dahingerafft wurden und denen die traditionelle Medizin nicht mehr helfen konnte. Daher geht es auch in dieser zweiten, erweiterten Auflage der "Quadratur des Kreises in der Medizin" um die Frage, ob es alternative Möglichkeiten bei der Krebsbekämpfung gibt. Die in der ersten Auflage beschriebenen Therapien des Krebsarztes Frank Daudert wurden inzwischen erweitert und sollen nun vorgestellt werden. Neuerdings leitet Frank Daudert, dem kürzlich die Lomonossow-Universität in Moskau den Professorentitel verliehen hat, neben der Praxisklinik in Bad Aibling auch noch ein europäisches Kompetenzzentrum für biologische Medizin in Igls. Das Prinzip Hoffnung möge diese alternative Klinik beflügeln und dazu beitragen, daß neue Erkenntnisse bei der Krebsbekämpfung gewonnen werden.

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