Mechanisms of Vascular Defects in Diabetes Mellitus

Section 1 Introduction.- The Global Burden Of Diabetes And Its Vascular Complications.- SECTION 2 Pathogenesis.- Genetic Basis For Increased Risk For Vascular Diseases In Diabetes.- Vascular Remodelling In Diabetes Mellitus.- Pathogenesis Of The Plaque Vulnerability In Diabetes Mellitus.- Endothelial Dysfunction In Diabetes.- Smooth Muscle Cells In Diabetes Mellitus.- Monocytes Factors In Pathogenesis Of Vascular Lesions In Diabetes.- Endothelial Progenitor Cell Dysfunction In The Pathogenesis Of Vascular Complications Of Diabetes.- Pathogenetic mechanisms in diabetic retinopathy: from molecules to cells to tissues.- Perspectives on the vascular pathogenesis of diabetic neuropathy.- SECTION 3 Molecular mechanisms.- The Renin - Angiotensin System And Diabetes.- Adipokines And Vascular Disease In Diabetes.- G-Proteins In Vascular Complications Of Diabetes.- Histone Deacetylases In Vascular Pathophysiology: Regulation By Vasoactive Peptides And Growth Factors.- Role of non-coding RNAs in vascular complications of diabetes mellitus.- SECTION 4 Hemostatic Factors.- Diabetes As A Prothrombotic State.- Mechanisms Of Hypercoagulation And Aberrant Clot Lyses In Type 2 Diabetes.- Platelet Dysfunction In Type-2 Diabetes Mellitus.- SECTION 5 Metabolic Factors.- Advanced Glycation End Products In Diabetic Complications.- Atherogenicdyslipoproteinemia In Type 2 Diabetes Mellitus.- Vascular Remodeling: Homocysteine And Diabetes.- SECTION 6 Pharmacological Therapies.- Mechanisms Of Action Of Drugs For Treating Endothelial Dysfunction In Diabetes Mellitus.- Beneficial Effects Of Inorganic Nitrate/Nitrite On Vascular Function And Blood Pressure In Diabetes.- Myeloperoxidase (MPO): Do We Need Inhibitors?.